Saffron (Crocus sativus) Ethanolic Extract and its Constituent, Safranal, Inhibits Morphine-induced Place Preference in Mice
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چکیده
منابع مشابه
Effects of aqueous saffron extract (Crocus sativus L.) on the acquisition and reinstatement of morphine-induced conditioned place preference in mice
Objective: In the present study, the effects of aqueous saffron extract (Crocus sativus L.) on the acquisition and reinstatement of morphine-induced conditioned place preference (CPP) in mice were investigated. Materials and Methods: Subcutaneous administration of morphine (40 mg/kg for four days) produced place preference. Intraperitoneal administration of aqueous extract (40 and 80 mg/kg for...
متن کاملEffects of aqueous saffron extract (Crocus sativus L.) on the acquisition and reinstatement of morphine-induced conditioned place preference in mice
Objective: In the present study, the effects of aqueous saffron extract (Crocus sativus L.) on the acquisition and reinstatement of morphine-induced conditioned place preference (CPP) in mice were investigated. Materials and Methods: Subcutaneous administration of morphine (40 mg/kg for four days) produced place preference. Intraperitoneal administration of aqueous extract (40 and 80 mg/kg for ...
متن کاملEffect of Crocus sativus extracts and its active constituent safranal on the harmaline-induced tremor in mice
OBJECTIVES Due to unsatisfactory response or intolerable side effects of current drugs, treatment of essential tremor remains inadequate. Thus, we aimed to investigate the protective and therapeutic effects of aqueous and ethanolic extracts of Crocus sativus (saffron), and its active consistent, safranal, on the harmaline-induced tremor in mice. MATERIALS AND METHODS To induce tremor, harmali...
متن کاملCrocus Sativus L. (Saffron) Extract and its Active Constituents (Crocin and Safranal) on Ischemia-Reperfusion in Rat Skeletal Muscle
Saffron and its constituents have been shown to decrease ischemia-reperfusion (I/R) injury in kidney or brain tissues. In this study, the effects of saffron ethanolic extract and its constituents, crocin and safranal, were evaluated in skeletal muscle during I/R injury. Hind limb ischemia was induced using clamping the common femoral artery and vein. After 2 h ischemia, the clamp of the femoral...
متن کاملEffect of Crocus sativus extracts and its active constituent safranal on the harmaline-induced tremor in mice
Objective(s): Due to unsatisfactory response or intolerable side effects of current drugs, treatment of essential tremor remains inadequate. Thus, we aimed to investigate the protective and therapeutic effects of aqueous and ethanolic extracts of Crocus sativus (saffron), and its active consistent, safranal, on the harmaline-induced tremor in mice. Materials and Methods: To induce tremor, harma...
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ژورنال
عنوان ژورنال: Pakistan Journal of Biological Sciences
سال: 2011
ISSN: 1028-8880
DOI: 10.3923/pjbs.2011.939.944